MEDICINAL
CHEMISTRY-II – 4Th B-Pharm (75 Hours)
First Sessional
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Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
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01. |
Chapter
No-01 |
Modern
concept of rational drug design: |
A)
A brief introduction to quantitative structure activity relationship (QSAR), Prodrug, Combinatorial Chemistry and Computer Aided Drugs
Design.(CADD). B) History and development of chemotherapeutic
agents: Structure,uses and synthesis of only
those compounds that are underlined and superscribed
by ‘s’ c) Anti-infective agents: 1. Local
anti-infective agents: a)
Alcohols and related compounds: Alcohol,isopropyl alcohol,formaldehyde soloution. b)
Phenols and their derivatives:p-Chloro phenol,
hexachlorophene, Resorcinol, hexyl resorcinol. c)
Oxidizing agents: Hydrogen peroxide soloution,
hydrous benzoyl peroxide. d)
Halogen containing compounds: Iodine tincture, Chlorine containing compounds-halozone. e)
Cationic surfactants:Benzalkonium chloride, cetylpyridinium chloride. f)
Dyes-Gentain Violet, Methylene
blue. g)
Nitrogen compounds: Nitrofurazone, Furazolidone. |
(04 Hours) (03 Hours) |
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02. |
Chapter
No-02 |
Preservatives |
a)
b)
Miscellaneous: Chlorobutanol, Benzyl alcohol, Phenylethyl alcohol, Sodium benzoate, Phenyl mercuric
nitrate, Phenyl mercuric acetate. |
(0 1Hours) |
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03. |
Chapter
No-03 |
Antifungal
agents |
a)
Antifungal antibiotics-Nystain, Candicidin,
Hamycin, Griseofulvin Ampoterecin-B. Synthesis anti fungal agents b)
Substituted imidazoles: Clotrimazole,
Miconozole, Ketoconazole. c)
Miscellaneous –Zinc propionate, Sodium caprylate, Tolnaftate. |
(03 Hours) |
|
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04. |
Chapter
No-04 |
Urinary
tract anti-infectives |
a)
Quinolones: Nalidixic
acid, Cinoxacin, Norfloxacin,
Ciprofloxacin, Pefloxacin, Ofloxacin,
Sparfloxacin. b)
Miscellaneous : Nitrofurantoin. |
(02 Hours) |
|
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05. |
Chapter
No-05 |
Antiubercular drugs: SAR of antiubercular drugs, |
a)
Synthesis antiubercular agents: p-Aminosalysilic acid, Isoniazid,
Ethambutols, Pyrazinamide,
Ethionamide, Clofazimine. b)
Antiubercular Antibiotic: Cycloserine,
Viomycin sulfate, Capreomycin
sulfate, Rifampicin. |
(04 Hours) |
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|
06. |
Chapter
No-06 |
Anti
viral agents |
a)
Amantidine hydrochloride, Iodoxuridine,
Zidovudine. b)
Anti-AIDS: Aza thymidine,
Suramin. |
(02 Hours) |
|
|
07. |
Chapter
No-07 |
Antiprotozoal agents |
Emetine
hydrochloride, Metronidazole, Diloxanide
furoates, 8-hydroxy Quinoline
derivatives ( clioquinal, iodoquinal),
Carbarsone. |
(02 Hours) |
|
|
08. |
Chapter
No-08 |
Anthelmintics |
Piperazine, Diethyl carbamazine, Pyrantel pamoate, Thiabendazole, Mebendazole, |
(02 Hours) |
|
Second Sessional
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Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
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D) Sulfonamides, Sulfones as antibacterial agents: 1. SAR
of Sulfonamides. 2.
Classification of sulfonamides based on duration of action with example. Sulfamethiazole, Sulfisoxazole,
Sulfapyridine, Sulfamethoxazole,
Sulfadiazine, Sulfacetaminde, Sulfasalazine,
Phthalyl Sulfathiazole. 3.
Folate reductase
inhibitors: Trimethoprim, Synergistic action of the
combination of Sulfamethoxzole and trimethoprim. 4.
Sulfone : Dapsone. E) Antimalarials : Ethiology
of malaria, Histroy, Mechanism and SAR. 1. Quinolines and
analogues: 7-chloro-4-amino
quinolines: Chloroquine
phosphates, Hydroxy Chloroquine.
Sulphate,Amodiaquine. 8-amino quinolines:
Pamaquine Primaquines,
9-amino acridines: Quinacrines. 2. Miscellaneous: Mefloquine, Pyrimethamine,
Trimethoprine. 3. Biguanides and Dihydrothiazines:Chloroguanide, Cycloguanil. F) Antibiotics: Historical background, Mechanism of action,
classification. 1. Beta lactam
antibiotic: Pencellins- Structure, chemical
degradation bacterial resistance Penicillin G, Penicillin V, Cloxacillin sodium, Naficillin
sodium, Ampicillin, Amoxcyllin. 2. Beta lactamase
inhibitors: Clavulanic acid and its salt, Thienamycin. 3. Cephalosporins: Structure and uss of Cephalexin, Cephradine, Cefadroxil, Cefixime, Cefapyridine, Cefutroxime. 4. Monolactams: Sulfazecin, Aztreonam,
Tigmonam. 5. Aminoglycosides: Structural features and
Mechanism of action, Streptomycin, Amikacin
neomycin, Kanamycin, Gentamycin,
Netilmycin. 6. Teracyclines: Chemistry and SAR,
tetracycline, chloretracyline, Methacycline,
Demeclocycline, Oxytetracycline,
Meclocycline, Doxycycline,
Minocycline. 7. Macrolide: Structure and specific
uses of Erthromycin, Azithrocin,
Oleandomycin. 8. Lincomycins:Lincomycin, Clindamycin. 9. Polypeptides: Gramicidin, Bacitracin,
Polymyxin B, Colistin. 10. Miscellaneous: Chlormphenicol, Vancomycin,
Novobiocin.
I.) Diuretics: Introduction 1)
Carbonic anhydrase inhibitors: Acetazolamide,
Methazolamide. 2) Thiazide and Thiazide like diuretics: Chlorthiazides, Benzthiazide,
Xipamide, Chlorthaildone. 3) High-ceiling or loop diuretics: Furosemide,
Ethacrynic acid. 4) Potassium sparing diuretics: Spironolactone,
Triampterene, Amiloride. 5) Miscellaneous: Mannitol. |
(04 Hours) (04 Hours) (06Hours) (06 Hours) (05 Hours) |
Third Sessional
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Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
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G) Antineoplastic agents
: Introduction,
mechanism, of action and classification with example. 1. Alkylating agents: Mechlorethamine,
Cyclophosphamide, Melphalan,
Chlorambucil, Busulfan, Lomustine. 2. Antimetabolities: Mercaptopurine, Thioguanine,
5-Flurouracil, Methotrexate, 3. Antibiotics: Dactinomycin, Bleomycin,
Mitomycin, Streptozocin. 4. Plant Product: Etopside, Taxol,
Camphothesin, Vincristine,
Vinblastin.
5. Harmones: Dromostanalone, Megestrol. 6. Miscellaneous : Asparginase, Cisplatin,
Hydroxy urea. 7. Immunotherapy:Interferon alpha 2a and 2b. H) Cardiovascular agents: 1.
Antianginal agents and vasodilators: Chemical structure
and specific uses of Amyl nitrite, Nitroglycerine, Isosorbide
dinitrate. 2. Calcium
antagonists: Brief introduction of calcium channels and thir
blockers, Chemical structure and uses of verapamil,
Diltiazem, Nifedepine, Nimodepine, Felodepine Dipyridamole, Cyclandelate. 3.
Antiarrythmics drugs: structure chemical name and
classification of antiarrythmics with example. Class-I
membrane depressant drugs: Quinidine Procainamide, Phenytoin. Class-II-Beta
Adrenergic blocking agents, Tocainide, Propranolol. Class-II-
Repolarization prolongators,
Bretylium, Amiodarone. ClassIV- Clacium
channel blocker, Diltiazem, Verapamil. |
(04 Hours) (03 Hours) (02 Hours) (01 Hours) (02 Hours) (03 Hours) (02 Hours) |
|
09. |
Chapter
No-09 |
Antihypertensive
agents |
Beta-blockers:
Propranolol. Timolol. ACE
inhibitors : Captopril, Enalapril. Diuretics:
Hydrochlorthiazide, Spiranolactone Calcium
channel blockers: Nifedipine, Felodepine,
Amlodepine a1-Antagonist
: Prazocin. A2-against:
Clonidine, Guanithedine. Miscellenous: Resprepine,
Hydralazine, Minixidil. |
(02 Hours) (02 Hours) |
|
10. |
Chapter
No-10 |
Antihyperlipidemic agents: |
Structure
and specific uses. Clofibrate, Lovastatin,
Cholestramine, Colestipol. |
(02 Hours) |
|
11. |
Chapter
No-11 |
Anticoagulants |
Dicumorol, Warfarin,
Phenindione. |
(01 Hours) |
|
12. |
Chapter
No-12 |
Hypoglycemic
agents |
Sulfonyl vureas-Chlorpropamide.
Acetohexamide, Glipizide. |
(02 Hours) |
|
13. |
Chapter
No-13 |
Thyroid
Hormones |
L-Thyroxine, L-Thyroxine. |
(0.5 Hours) |
|
14. |
Chapter
No-14 |
Antithyroid drugs |
Propylthiouracil, Methimazole. |
(0.5 Hours) |