LUQMAN COLLEGE OF PHARMACY, GULBARGA

 

PHYSICAL PHARMACEUTICS – 2ND  B-Pharm (75 Hours)

 

First Sessional

 

Sl.No.

Chapter No

Topic

Sub Topic

Hours

01

Chapter No-01

Interfacial phenomenon

Liquid interfaces, adsorption at liquid/solid interfaces, adsorption isotherms, concept of contact angle, hydrophile lipophile balance, spreading coefficient, Gibb’s adsorption equation, electrical properties of interfaces.

 

07 Hours

 

02

Chapter No-02

Solubility phenomena

Solvent-solute interaction, solubility of gas in liquids, solubility liquids, in liquids (binary solution, ideal solution, Raoult’s law, real solution, distillation on binary mixture, azeotropic mixtures and fractional distillation. Partially miscible liquids (conjugate mixture), critical solution temperatures, applications, phenol-water system, triethylamine-water system, nicotine –water system. Solubility of solids in liquids: Definition, determinations, factors influencing the solubility.

 

 

08 Hours

03

Chapter No-03

Distribution law

Explanation, limitation and application, effect of molecular association, dissociation and complexation.

 

05 Hours

04

Chapter No-04

Rheology

Newtonain and non-newtonain system, thixotropy, determination of rheological properties Single and multipoint instruments and Applications to pharmacy.

 

06 Hours

 

 

 

 

Second Sessional

 

Sl.No.

Chapter No

Topic

Sub Topic

Hours

05

Chapter No-05

PH buffers and isotonic solution

Sorensen’s PH determination (electrometric and calorimetric), application, buffer equation, buffer capacity, buffer in pharmaceutical and biological system, application, buffered isotonic solution.

07

Hours

06

Chapter No-06

Diffusion and dissolution

Steady state diffusion, types of diffusion, diffusionequation, diffusion cells, Dissolution of tablets and capsules, Hixon-crowell cube root law. Dissolution apparatus; factors affecting dissolution.

 

06 Hours

 

07

Chapter No-07

 

Colloids

Definition types,preparation, purification stablization of colloids, properties optical properties, kinetic properties, electrical properties.Donnan membrane phenomenon

 

 

06 Hours

 

08

Chapter No-08

 

Coarse dispersions: Suspensions:

Settling in Suspension, Wetting, Controlled flocculation-flocculation in structured vehicals, Rheological consideration,preparation,physical stability and evaluation of suspension.

Emulsions : Definition, mechanism of action of emulsifying agents, theories of emulsification. Formulation of emulsions-instability of emulsions, evaluation of emulsion stability. Rheology of mulsion, microemulsions, multiple emulsion.

 

 

06 Hours

 

 

 

 

Third Sessional

 

Sl.No.

Chapter No

Topic

Sub Topic

Hours

09

Chapter No-09

Kinetics

Rates and molecularity of the reaction, determination of order, factors influencing rate of reaction, stabilization of drugs, applications of chemical kinetics to the stability testing of pharmaceuticals. Simple numerical problems. 

08 Hours

10

Chapter No-10

Micromeritics

Particle size distribution, methods for determining particle size, shape and surface area. Derived properties of powders, simple numerical problems.

 

06 Hours

 

11

Chapter No-11

Complexation

Types of complexes, metal complexes, organic molecular complexes, inclusion compounds, methods of analysis of complexes.

 

05 Hours

 

12

Chapter No-12

Physical properties of drug molecule

Refractive index, optical rotation, dielectric constant, dipole moment, dissociation, determination and application.

 

05 Hours