PHYSICAL
PHARMACEUTICS – 2ND B-Pharm (75
Hours)
First Sessional
Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
01 |
Chapter
No-01 |
Interfacial
phenomenon |
Liquid
interfaces, adsorption at liquid/solid interfaces, adsorption isotherms,
concept of contact angle, hydrophile lipophile balance, spreading coefficient, Gibb’s
adsorption equation, electrical properties of interfaces. |
07 Hours |
02 |
Chapter
No-02 |
Solubility
phenomena |
Solvent-solute
interaction, solubility of gas in liquids, solubility liquids, in liquids
(binary solution, ideal solution, Raoult’s law,
real solution, distillation on binary mixture, azeotropic
mixtures and fractional distillation. Partially miscible liquids (conjugate
mixture), critical solution temperatures, applications, phenol-water system, triethylamine-water system, nicotine –water system.
Solubility of solids in liquids: Definition, determinations, factors
influencing the solubility. |
08 Hours |
03 |
Chapter
No-03 |
Distribution
law |
Explanation,
limitation and application, effect of molecular association, dissociation and
complexation. |
05 Hours |
04 |
Chapter
No-04 |
Rheology |
Newtonain and non-newtonain system, thixotropy,
determination of rheological properties Single and multipoint instruments and
Applications to pharmacy. |
06 Hours |
Second Sessional
Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
05 |
Chapter No-05 |
PH
buffers and isotonic solution |
Sorensen’s PH determination (electrometric and calorimetric), application, buffer equation, buffer capacity, buffer in pharmaceutical and biological system, application, buffered isotonic solution. |
07 Hours |
06 |
Chapter
No-06 |
Diffusion
and dissolution |
Steady
state diffusion, types of diffusion, diffusionequation,
diffusion cells, Dissolution of tablets and capsules, Hixon-crowell
cube root law. Dissolution apparatus; factors affecting dissolution. |
06 Hours |
07 |
Chapter
No-07 |
Colloids |
Definition
types,preparation, purification stablization
of colloids, properties optical properties, kinetic properties, electrical properties.Donnan membrane phenomenon |
06 Hours |
08 |
Chapter
No-08 |
Coarse
dispersions: Suspensions: |
Settling
in Suspension, Wetting, Controlled flocculation-flocculation in structured vehicals, Rheological consideration,preparation,physical stability and evaluation of
suspension. Emulsions
:
Definition,
mechanism of action of emulsifying agents, theories of emulsification.
Formulation of emulsions-instability of emulsions, evaluation of emulsion
stability. Rheology of mulsion,
microemulsions, multiple emulsion. |
06 Hours |
Third Sessional
Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
09 |
Chapter
No-09 |
Kinetics |
Rates
and molecularity of the reaction, determination of
order, factors influencing rate of reaction, stabilization of drugs,
applications of chemical kinetics to the stability testing of
pharmaceuticals. Simple numerical problems.
|
08 Hours |
10 |
Chapter
No-10 |
Micromeritics |
Particle
size distribution, methods for determining particle size, shape and surface
area. Derived properties of powders, simple numerical problems. |
06 Hours |
11 |
Chapter
No-11 |
Complexation |
Types
of complexes, metal complexes, organic molecular complexes, inclusion
compounds, methods of analysis of complexes. |
05 Hours |
12 |
Chapter
No-12 |
Physical
properties of drug molecule |
Refractive
index, optical rotation, dielectric constant, dipole moment, dissociation,
determination and application. |
05 Hours |