PHARMACEUTICAL
ORGANIC CHEMISTRY – II – 2nd B-Pharm (75
Hours)
First Sessional
|
Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
|
01. |
Chapter
No-01 |
Heterocyclic
Chemistry |
Genral classification of heterocylic compounds, nature and nomenclature, reaction,
synthesis and properties of the following heterocyclic system and their
derivatives. a)
Pyrrole, furan and Thiophene b)
Fused ring systems involving Pyrrole, Furan, Thiophene, Indole and Benzofuran. c)
Pyridine d)
Quinoline, Isoquinoline, acridine. e)
Pyrazole, Imidazole, Oxazole, Isoxazole. f)
Pyrimidine, Pyrazine, Pyridazine, Purine,
benzodiazepines. |
(07 Hours) (04 Hours) (03 Hours) (04 Hours) |
|
02 |
Chapter
No-02 |
Stereochemistry |
1.
Stereo isomerism, tetrahedral optical activity, enantiomerism,
diastereoisomerism,meso structure, elements of
symmetry, chirality, chiral
centers, reaction of chiral molecules,
configuration, spcification of D and L configration. Nature of E and Z forms. Recemic modification and resolution of recemic mixture, conformational isomers, asymmetric
synthesis. |
(12 Hours) |
Second Sessional
|
Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
|
|
|
|
2.
Stereo selective and steriospecific reaction. Stereo
chemical mechanism for the following reaction such as addition of halogen to
alkenes, E1 and E2 reactions, syn and anti
reactions, and Nucleophilic substitution reaction. 3.
Geometrical isomerism, its nature of formation, rotation about bonds; nomenclature
of isomers, determination of configiration. 4.
Stereochemistry of alicyclic compounds and
biphenyls, stereochemistry of oximes. 5.
Study of basic structure, compound having pharmacological activity/medicinal
compounds of tricyclic hetero ring systems-phenothiazines, and benzodiazepines. 6.
Structure and medicinal uses of the following official compounds. 1.
Phenazone 2. Nicotiniacid
3. Nikethamide 4. Isoniazid
5. Mepyramine 6. Benzhexol
7. Histamine 8.Chloroquine 9. Carbimazole 10. Pyreimethamine 11. Pipe-razine 12.
Diazepam 13. Diethylcarbamazine citrate 14.
Sulphadiazine 15. Metronidazole. |
(04 Hours) (04 Hours) (03 Hours) (03 Hours) (03 Hours) |
|
03. |
Chapter
No-03 |
Poly
Nuclear Hydrocarbons; |
Synthesis
( Haworth’s and Diels Alder) properties and reaction
of Naphthalene, Phenanthrene and Anthracene. Structure and medicinal uses of Propranolol, Tolnaftate, Menadione, Naphzoline,Phenindione, Morphine and Codeine. |
(04 Hours) |
Third Sessional
|
Sl.No. |
Chapter
No |
Topic |
Sub
Topic |
Hours |
|
04. |
Chapter
No-04 |
Chemistry
of bio molecules of pharmaceutical importance: |
1. Carbohydrate. Introduction,
Definition, Classification, Nomenclature, Structural Determination of Glucose
and Fructose. Stereoisomers of monosaccharides,
reaction conversion, cofiguration, cyclic structure
of glucose, determination of ring size in Glucose. Fischer projection formulae, and conformations. Disaccharides and
polysaccharides, Chemical nature of maltose, lactose, sucrose, starch and
cellulose, derivatives used in pharmacy. 2.Fats and Oils: Chemistry
of fats oils and waxes. Occurance and composition.
Hydrolysis of fats, esterification. Fats as sources
of pure acids and alcohols. Analytical constant of fats and oils. Methods of
their determination and significance. Unsaturated fats, hardening of oils,
hydrogenation of oils, drying, semidrying and nondrying oils. 3. Proteins and Amino acids: Introduction,
definition, classification of proteins and amino acids and their properties,
reaction, synthesis of amino acids (Gabreil’s Pthalimide, synthesis, Strecker’s
synthesis, Koop’s and Erlenmeyer’s azalactone
synthesis). Peptide linkages, structure of proteins, C-terminal and
N-terminal analysis. Isoelectric points and its
significance. |
(09 Hours) (03 Hours) (06 Hours) |